• Semi-syntheticderivativeofgeldanamycin,Cat.No.G-4500,demonstratinggreaterstABIlityandlowerinvivotoxicitythanitsparentcompound.17-AAGbindsspecificallytoheatshockproteinHsp90inamannersimilartogeldanamycin,butthebindingisweaker.Schulte,T.W.andNeckers,L.M."Thebenzoquinoneansamycin17-allylamino-17-demethoxygeldanamycinbindstoHSP90andsharesimportantBIOLOGicactivitieswithgeldanamycin."CancerChemother.Pharmacol.42:273-279(1998).
• InhibitsAktactivationandHER2expressionintumorcells.Basso,A.D.,etal."AnsamycinantibioticsinhibitAktactivationandcyclinDexpressioninbreastcancercellsthatoverexpressHER2."Oncogene21:1159-1166(2002).
• Exhibits100-foldhigherbindingaffinityfortumor-cell-derivedhsp90overthatderivedfromnormalcells.Kamal,A.,etal."Ahigh-affinityconformationofHsp90conferstumourselectivityonHsp90inhibitors."Nature425:407-10(2003).
• Sensitizestumorcellstogrowtharrestandapoptosisinducedbypaclitaxel,Cat.No.P-9600.Nguyen,D.M.,etal."Sequence-dependentenhancementofpaclitaxeltoxicityinnon-smallcelllungcancerby17-allylamino17-demethoxygeldanamycin."J.Thorac.Cardiovasc.Surg.118:908-915(1999)andSolit,D.B.,etal."Inhibitionofheatshockprotein90functiondown-regulatesAktkinaseandsensitizestumorstoTaxol."CancerRes.63:2139-2144(2003).
• Sensitizescoloncancercellstocisplatin-inducedcelldeath.Vasilevskaya,I.A.,etal."Quantitativeeffectsonc-JunN-terminalproteinkinasesignalingdeterminesynergisticinteractionofcisplatinand17-allylamino-17-demethoxygeldanamycinincoloncancercelllines."MolPharmacol.65:235-243(2004).
• Inhibitsangiogenesis.Kaur,G,etal."Antiangiogenicpropertiesof17-(dimethylaminoethylamino)-17-demethoxygeldanamycin:anorallybioavailableheatshockprotein90modulator."Clin.CancerRes.10:4813-4821(2004).
• Soldforlaboratoryormanufacturingpurposesonly;notforhuman,medical,veterinary,food,orhouseholduse.

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