• BindsspecificallytoheatshockproteinHSP90anditsGP96homologue;inhibitsproteinmaturation.Whitesell,L.andCook,P."Stableandspecificbindingofheatshockprotein90bygeldanamycindisruptsglucocorticoidreceptorfunctioninintactcells."Mol.Endocr.10:705-712(1996).
• StABIlity:Geldanamycin"smethoxygrouponthequinoneringisreactive--itcanbedisplacedbyotheralcoholsorwater.Thus,geldanamycinisunstableinwaterandethanol,andthosesolventsshouldnotbeusedformakingstocksolutions.Althoughgeldanamycinstabilityinmethanolwouldnotbeaproblem(becausenostructuralchangeoccursifthegeldanamycinreactswithmethanol--itisjustamethoxyinterchange),solubilityinmethanolisverypoor.DMSOitselfprobablydoesnotreactwithgeldanamycin,butDMSOcancontainmoisturefromtheairand/orsmallamountsofDMSOdegradationproductsthatmightreactwithgeldanamycin.Thus,DMSOstocksolutionsshouldbekeptoutofcontactwithairtothegreatestextentpossIBLe.
• SolubilityinWater:Geldanamycinisverypoorlysolubleinwater;maximumsolubilityinplainwaterisestimatedtobeabout20-50uM;buffers,serumorotheradditivesmayincreaseordecreasetheaqueoussolubility.Althoughgeldanamycinissomewhatunstableinwater,itisofcourseunavoidablethatBIOLOGicaltestingofgeldanamycinwillexposethecompoundtowater.Wedonothaveanydataontheactualrateofgeldanamycindecompositioninwaterorotheraqueousmedia.
• Forverysimilarbutmuchmorestablegeldanamycinanalogs,pleasesee17-AAG,Cat.No.A-6880and17-DMAG,HydrochlorideSalt,Cat.No.D-3440.
• Soldforlaboratoryormanufacturingpurposesonly;notforhuman,medical,veterinary,food,orhouseholduse.

RelatedTerms:

LC Laboratories公司提供信号转导，调节蛋白亚细胞定位试剂（抗生素）产品蛋白抑制剂产品。热门产品 Bortezomib硼替佐米（99%，97%） Cyclosporine-A环胞霉素A Cyclopamine环巴胺 17-DMAG，Hydrochloride Salt HSP90抑制剂 Everolimus依维莫司 FK-506他克莫司 Forskolin腺苷酸环化酶激活剂 Gefitinib吉非替尼 Leptomycin B细霉素B出核转运抑制剂 LY 294002 PI3-K抑制剂 PD98059 MEK抑制剂 RoscovitineCDK抑制剂 Rapamycin雷帕霉素 SB 202190 MAPK抑制剂 SB203580 P38MAPK抑制剂 SP600125 JNK抑制剂 Staurosporine星孢菌素 UO126 MAPK抑制剂