• Ingenol-3-hexanoatewasmorepotentinreactivatinglatentHIVthanotherknownactivatorssuchasSAHA,ingenol3,20-dibenzoate,TNF-α,PMAandHMBA.Ingenol-3-hexanoatealonewasabletoreactivatevirustranscriptioninprimaryHIV-infectedlatentcellsupto12fold,andupto25foldincombinationwithSAHA.PandelóJoséD.,etal."ReactivationoflatentHIV-1bynewsemi-syntheticingenolesters."Virology462-463:328-339(2014).
• SyntheticingenolderivativesreferredtoasingenolA,B,andCactivatedtheHIV-LTRinreportercelllinesandlatentvirusinhumanPBMCsatconcentrationsaslowas10nM.TheywerealsoabletoinhibitthereplicationofHIV-1subtypeBandCinMT-4cellsandhumanPBMCswithEC50valuesof0.02and0.09µMrespectively.AbreuC.M.,etal."DualroleofnovelingenolderivativesfromEuphorbiatirucalliinHIVreplication:inhibitionofdenovoinfectionandactivationofviralLTR."PLoSOne9:e97257(2014).
• Highlyactiveantiretroviraltherapy(HAART)effectivelysuppressesHIVviralreplication;however,itfailstoerADIcatelatentviralreservoirs.Ingenol-3-hexanoateisapotentactivatoroflatentHIVreservoirs,possIBLyviaproteinkinaseC[delta]-Nf-[kappa]Bsignaling.JiangG.,etal."ReactivationofHIVlatencybyanewlymodifiedIngenolderivativeviaproteinkinaseCδ-NF-κBsignaling."AIDS28:1555-1566(2014).
• RelatedCASnumbers:59086-90-7foringenol-3,20-dibenzoate.
• Soldforlaboratoryormanufacturingpurposesonly;notforhuman,veterinary,food,orhouseholduse
• ThisproductisofferedforR&Duseinaccordancewith(i)35USC271(e)+A13(1)intheU.S.;(ii)Section69.1ofJapanesePatentLawinJapan;(iii)Section11,No.2oftheGermanPatentActof1981inGermany;(iv)Section60,Paragraph5boftheU.K.PatentsActof1977intheU.K.;(v)Sections55.2(1)and55.2(6)andothercommonlawexemptionsofCanadianpatentlaw;(vi)Section68BofthePatentsActof1953inNewZealandtogetherwiththeamendmentofsamebytheStatutesAmendmentBillof2002;(vii)suchrelatedlegislationand/orcaselawasmaybeorbecomeapplicableintheaforementionedcountries;and(viii)suchsimilarlawsandrulesasmayapplyinvariousothercountries.
• Notavailableinsomecountries;notavailabletosomeinstitutions;notavailableforsomeuses.

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