• K252aisakinaseinhibitorthatinhibitsPKA(Ki=18nM),PKC(Ki=25nM),andPKG(Ki=20nM).Kase,H.,etal."K-252compounds,novelandpotentinhibitorsofproteinkinaseCandcyclicnucleotide-dependentproteinkinases."Biochem.Biophys.Res.Commun.142:436-440(1987).
• PotentlyinhibitsCaMK(Ki=1.8nM),competitivelywithATPandnoncompetitivelywiththesubstrate.Hashimoto,Y.,etal."PotentandpreferentialinhibitionofCa2+/calmodulin-dependentproteinkinaseIIbyK252aanditsderivative,KT5926."Biochem.Biophys.Res.Commun.181:423-429(1991).
• Potentlyinhibitsphosphorylasekinase(IC50=1.7nM),with300-foldselectivityforthisenzymeoverproteinkinaseC.Elliott,L.H.,etal."K252aisapotentandselectiveinhibitorofphosphorylasekinase."Biochem.Biophys.Res.Commun.171:148-154(1990).
• Potentinhibitorofthetyrosinephosphorylationofp140prototrk;K252aalsohasadirecteffectonthep140prototrktyrosinekinase.Berg,M.M.,etal."K-252aInhibitsNerveGrowthFactor-inducedtrkProto-oncogeneTyrosinePhosphorylationandKinaseActivity."J.Biol.Chem.267:13-16(1992).
• Potentinhibitorofpp42/44MAPkinaseinvitroandinvivo.Lloyd,E.D.andWooten,M.W."pp42/44MAPkinaseisacomponentoftheneurogenicpathwayutilizedbynervegrowthfactorinPC12cells."J.NeuRochem.59:1099-1109(1992).
• K252aapparentlyinducesapoptosisbysuppressingphosphorylationofRb,upregulatingp21,andinhibitingCdc2andCdc25cactivity.Mohri,T.,etal."K252ainducescellcyclearrestandapoptosisbyinhibitingCdc2andCdc25c."CancerInvest.17:391-395(1999).
• Soldforlaboratoryormanufacturingpurposesonly;notforhuman,medical,veterinary,food,orhouseholduse.
• Wenotethatoneofourcompetitors,AGScientific,asofFebruary11,2014,isclaiming99.86%purityforitsK252a.ThisclaimisnotcredIBLeingeneralchemicaltermsforthiscomplexorganiccompound,norintermsofthesensitivityandreproducibilityofgenerallyutilizedanalyticaltechniques.

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