请使用支持JavaScript的浏览器!
主营:蛋白酶抑制剂,激酶抑制剂
℡ 4000-520-616
℡ 4000-520-616
LC Labs/P-6522 Perifosine, >99%/P-6522/500 mg
产品编号:P-6522
市  场 价:¥22600.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$1130.00
品      牌: LC Labs
公      司:LC Laboratories
公司分类:
LC Labs/P-6522 Perifosine, >99%/P-6522/500 mg
商品介绍
  • Perifosine,alsoknownasKRX-0401,isanovelsyntheticalkylphospholipidandisanewkindofantitumoragentwhichtargetscellmembranesandblocksAktactivation.
  • Thestructureofperifosineissimilartonaturally-occurringphospholipids.Perifosine(5µM)inhibitedthegrowthofPC-3prostatecarcinomacellsby50%in24hrandinducedcelldeathinvirtuallyallcellsby48hr.Kondapaka,S.B.,etal."Perifosine,anovelalkylphospholipid,inhibitsproteinkinaseBactivation."Mol.CancerTher.2:1093-1103(2003).
  • Perifosineinhibitsthegrowthofvariantcells,withGI50valuesof1-10µMforK-562,SUDHL-7,HL-60,PC-3,Colo-205,andMESA-SA(CRL-1976)cells,11-30µMforMG-63(CRL-1427),H-3386,RD(CCL-136),HT-29,MDA-435,SW-620,CCRF-7,H-1355,SAJA-1(CRL-2098),andDU-145cells,and>30µMforMCF-7,Hos(CRL-1543),andLnCAPcells.Kondapaka,S.B.,etal."Perifosine,anovelalkylphospholipid,inhibitsproteinkinaseBactivation."Mol.CancerTher.2:1093-1103(2003).
  • PerifosinereducesAktactivitybyinhibitingphosphorylationofAktatbothThr308andSer473.Kondapaka,S.B.,etal.Perifosine,anovelalkylphospholipid,inhibitsproteinkinaseBactivation."Mol.CancerTher.2:1093-1103(2003).
  • Perifosineinhibitedthegrowthofbreast,ovarianandprostatecancersbyinducingapoptosis.PerifosineselectivelyblocksAKTrecruitmenttothemembraneanddown-regulatesthephosphorylationofAKTanditsdownstreamtargets,particularlyS6,invarioustumorcelllinesandxenografts.Hennessy,B.T.,etal."PharmacodynamicMarkersofperifosineefficacy."Clin.CancerRes.13:7421-7431(2007).
  • Perifosineinducessignificantinvitroandinvivocytotoxicityinhumanmultiplemyeloma(MM),whichisassociatedwithdown-regulationofAktphosphorylationintumorcells.c-JunN-terminalkinase(JNK)playsacriticalroleinperifosine-inducedapoptosis.Perifosineenhancesdexamethasone,doxorubicin,melphalanandbortezomib-inducedMMcellcytotoxicity.Hideshima,T.,etal."Perifosine,anoralbioactivenovelalkylphospholipid,inhibitsAktandinducesinvitroandinvivocytotoxicityinhumanmultiplemyelomacells."Blood107:4053-4062(2006).
  • NosignificantclinicalactivityofperifosineagainstandrogenindependentprostatecancerwasobservedinaphaseIIstudy.Posadas,E.M.,etal."AphaseIIstudyofperifosineinandrogenindependentprostatecancer."CancerBiol.Ther.4:1133-1137(2005).
  • Twenty-threepatientswithadvancedsofttissuesarcomareceived66cyclesoftreatmentwithperifosine(1cycle=4weeks).The3and6monthprogression-freesurvivalwas22%and9%.Bailey,H.H.,etal."PhaseIIstudyofdailyoralperifosineinpatientswithadvancedsofttissuesarcoma."Cancer107:2462-2467(2006).
  • Inchemicalstructureterms,perifosineisknownasa"betaine"or"zwitterion,"whichcanalsobereferredtoasan"internalsalt."Thesetermsareappliedtocompoundsthathaveanetneutralchargefortheentiremoleculebutwhichcontainbothapositively-chargedfunctionalgroup(suchasaquaternaryammoniumcationinthecaseofperifosine)andanegativelychargedfunctionalgroup,suchasaphosphateorcarboxylateanion.
  • Soldforlaboratoryormanufacturingpurposesonly;notforhuman,veterinary,food,orhouseholduse.
  • ThisproductisofferedforR&Duseinaccordancewith(i)35USC271(e)+A13(1)intheU.S.;(ii)Section69.1ofJapanesePatentLawinJapan;(iii)Section11,No.2oftheGermanPatentActof1981inGermany;(iv)Section60,Paragraph5boftheU.K.PatentsActof1977intheU.K.;(v)Sections55.2(1)and55.2(6)andothercommonlawexemptionsofCanADIanpatentlaw;(vi)Section68BofthePatentsActof1953inNewZealandtogetherwiththeamendmentofsamebytheStatutesAmendmentBillof2002;(vii)suchrelatedlegislationand/orcaselawasmaybeorbecomeapplicableintheaforementionedcountries;and(viii)suchsimilarlawsandrulesasmayapplyinvariousothercountries.
  • Notavailableinsomecountries;notavailabletosomeinstitutions;notavailableforsomeuses.
M.W.461.66
C25H52NO4P
[157716-52-4]
M.I.14:7165

Storage

Storeatorbelow-20ºC

Solubility

VerypoorlysolubleinDMSO;solubleinethanolat200mg/mL;solubleinwaterat50mg/mLwithwarming;buffers,serum,orotheradditivesmayincreaseordecreasetheaqueoussolubility

Disposal

A
品牌介绍

LC Laboratories公司提供信号转导,调节蛋白亚细胞定位试剂(抗生素)产品蛋白抑制剂产品。热门产品 Bortezomib硼替佐米(99%,97%) Cyclosporine-A环胞霉素A Cyclopamine环巴胺 17-DMAG,Hydrochloride Salt HSP90抑制剂 Everolimus依维莫司 FK-506他克莫司 Forskolin腺苷酸环化酶激活剂 Gefitinib吉非替尼 Leptomycin B细霉素B出核转运抑制剂 LY 294002 PI3-K抑制剂 PD98059 MEK抑制剂 RoscovitineCDK抑制剂 Rapamycin雷帕霉素 SB 202190 MAPK抑制剂 SB203580 P38MAPK抑制剂 SP600125 JNK抑制剂 Staurosporine星孢菌素 UO126 MAPK抑制剂

自营商城图标
厂家直采
全球直采 正品优价
正品保障图标
正品保障
厂家直发 有线跟踪
解放采购图标
正规清关
CIF100%正规报关,提供发票
及时交付图标
及时交付
限时必达 不达必赔